Defending champion Novak Djokovic has progressed to the third round after defeating Japanese wildcard Tatsuma Ito in Melbourne.
The Serb, who won 6-1, 6-4, 6-2 in one hour and 35 minutes, will now face Yoshihito Nishioka, who had crushed British number one Dan Evans in straight sets.
Sixth seed Stefanos Tsitsipas also reached the third round after opponent Philipp Kohlschreiber withdrew injured.
He will face Canadian Milos Raonic or Cristian Garin of Chile in the third round.
Birthday boy Monfils beats Vallejo in first round of his last US Open
French showman Gael Monfils has celebrated his 40th birthday with a 2-6 6-1 6-2 6-0 win over Adolfo Daniel Vallejo to reach the second round of the US Open on Tuesday, keeping his farewell Grand Slam campaign alive.
Home favourite Gauff storms past Sonmez at US Open
Home favourite Coco Gauff has begun her campaign for a second US Open crown with a 6-3 6-4 victory over Turkey's Zeynep Sonmez on Tuesday.
Rybakina quiets injury concerns with first-round win over Frodin
Second seed Elena Rybakina breathed a sigh of relief with her first-round win at the US Open on Tuesday, after a leg injury in Cincinnati made her doubt whether she could even play in New York.
Man City complete Fernandez signing from Chelsea
Manchester City has completed its summer spending in lavish fashion as Argentine midfielder Enzo Fernandez joined for a reported British record-equalling £125 million ($169.08 million) from Chelsea on Tuesday.
Keys tames nerves to beat Korneeva in US Open as Fritz, Cobolli advance
American Madison Keys overcame early jitters to down Russian Alina Korneeva 7-5 6-4 in the first round of the US Open on Tuesday.
His Highness Sheikh Hamdan bin Mohammed bin Rashid Al Maktoum, Crown Prince of Dubai and the UAE's Deputy Prime Minister and Defence Minister, has directed Dubai Future Week be held from November 18 to 21.
UAE President His Highness Sheikh Mohamed bin Zayed Al Nahyan has received Masrour Barzani, Prime Minister of the Kurdistan Region of Iraq, in the presence of His Highness Sheikh Mohammed bin Rashid Al Maktoum, Vice President and Prime Minister of the UAE and Ruler of Dubai.
Jordanian Katya Abu Al-Saud, who suffers from spinal muscular atrophy, has arrived in Dubai to begin life-saving treatment covered by His Highness Sheikh Mohammed bin Rashid Al Maktoum, Vice President and Prime Minister of UAE and Ruler of Dubai.
